In another blow to the people who like to tell themselves that Agents of S.H.I.E.L.D. isn’t set in the Marvel Cinematic Universe, the showrunners have confirmed that this final season will “bump” into something big from the MCU.
They made the statements in an interview with Deadline about the final season when asked if the show is going to cross over with anything from the MCU:
WHEDON: We’re going to bump into something.
LOEB: (laughs) Yeah, we’ll bump into something.
BELL: Something will definitely happen
Obviously they’re likely talking about the Snap/Blip, which this season has long been rumored to address. Recently the show’s VFX supervisor hinted that this final season will explain how the show was affected by the events of Avengers: Infinity War, so that’s most likely the “something” the show will “bump” into in its final season.